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Abstract Endometriosis is a chronic inflammatory hormone-dependent condition associated with pelvic pain and infertility, characterized by the growth of ectopic endometrium outside the uterus. Despite some progress in defining mode-of-action for drug development, the lack of reliable animal models indicates that novel approaches are required.
The difficulties inherent to modeling endometriosis are related to its multifactorial nature, a condition that hinders the recreation of its pathology and the identification of clinically relevant metrics to assess drug efficacy. In this review, we report and comment endometriosis models and how they have led to new therapies.
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Klapp global anti aging cream envision a roadmap for endometriosis research, integrating Artificial Intelligence, three-dimensional cultures and organ-on-chip models as ways to achieve better understanding of physiopathological features and better tailored effective treatments.
Keywords: Endometriosis, Animal model, Drug efficacy, Organ-on-chip, Cell culture, Artificial intelligence Background: setting and disease Endometriosis is a reproductive age-associated disease [ 12 ] that has become the target of intense investigation, as indicated by the increasing number of scientific papers published.
This surge of information directed to both laypersons klapp global anti aging cream healthcare professionals improved the identification of symptoms, augmented the odds of correct diagnosis as well as the awareness of available medical treatment [ 3 ]. The difficulties to reach the diagnosis comprise the need for clinical and surgical expertise to evaluate correctly the clinical symptoms and to detect the presence of ectopic endometrial implants so-called lesions in the peritoneal cavity and on pelvic organs [ 7 ].
Although imaging methods such as transvaginal ultrasonography with bowel preparation and magnetic resonance are common diagnostic tools, the gold standard diagnostic method for endometriosis is still the histopathological analysis of lesions collected during laparoscopic surgery [ 8 ].
The etiopathogenesis of endometriosis is not known. However, there are theories on the origin of endometriotic lesions anti aging hormon termékek kancáknak the peritoneal cavity.
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It is proposed by some investigators that stem cells originating the lesions are already there in the peritoneal cavity whereas others propose that endometrium cells are seeded there by retrograde menstruation. The pathophysiology, however, is strongly influenced by other factors such as genetic predisposition and hormonal factors such as resistance to progesterone, estrogen dependence; inflammation, angiogenesis, and vascularization processes, oxidative stress, resistance to apoptosis and immunological factors are also involved to various degrees in lesion development Fig.